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Any new cardiac symptoms, significant muscle weakness, or signs of dehydration warrant prompt medical evaluation and possible electrolyte testing

Weight-based dosing considerations The standard semaglutide protocol uses fixed doses (0.25 mg, 0.5 mg, 1 mg, 1.7 mg, 2.4 mg) regardless of body weight

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Since more than 80% of insulin-mediated glucose disposal during the euglycemic insulin clamp took place in skeletal muscle [55], these results indicated that the lowering plasma glucose concentration in T2DM significantly improved muscle insulin resistance